Ericsson eyes steady growth despite global downturn

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Competition and increased product commoditization have pressured prices in the industry for years. Europe\\'s debt crisis and weaker global growth squeezed vendors further. 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New drug target found for cystic fibrosis lung disease

ScienceDaily (Nov. 7, 2012) ? Vancouver researchers have discovered the cellular pathway that causes lung-damaging inflammation in cystic fibrosis (CF), and that reducing the pathway's activity also decreases inflammation. The finding offers a potential new drug target for treating CF lung disease, which is a major cause of illness and death for people with CF.

"Developing new drugs that target lung inflammation would be a big step forward," says Dr. Stuart Turvey, who led the research. Dr. Turvey is the director of clinical research and senior clinician scientist at the Child & Family Research Institute and a pediatric immunologist at BC Children's Hospital. He is an associate professor in the Department of Pediatrics at the University of British Columbia.

The research was published online last week in the Journal of Immunology.

For the study, researchers compared the immune response of normal lung cells with that of CF lung cells after exposing both types of cells to bacteria in the lab. In healthy cells, exposure to bacteria triggers the cell to secrete special molecules that attract immune cells to fight the infection.

In CF lung cells, the researchers discovered that a series of molecular events called the unfolded protein response is more highly activated. It causes the CF lung cells to secrete more molecules that attract an excessive amount of immune cells, which leads to increased inflammation.

They also found that treating the CF cells with a special chemical normalized the unfolded protein response and stabilized the cells' immune response.

CF is the most common genetic disease affecting young Canadians. One in every 3600 children born in Canada has CF. There is no cure. A build-up of mucus in the lungs causes people with CF to be susceptible to bacterial lung infections, which trigger inflammation and swelling. Over time, the recurring cycle of infections and inflammation damages the lungs and can lead to the need for lung transplantation. The only treatments for lung inflammation are steroids and anti-inflammatory medications, which can have significant side effects.

The researchers are planning further study to validate these findings in a larger number of lung cell samples from people with CF.

This discovery resulted from a collaboration among Vancouver investigators and trainees based at the Child & Family Research Institute at BC Children's Hospital, the University of British Columbia, and the Providence Heart + Lung Institute at St. Paul's Hospital.

This research was funded by Cystic Fibrosis Canada and the Michael Smith Foundation for Health Research.

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The above story is reprinted from materials provided by Child & Family Research Institute.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

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Journal Reference:

1. C. J. Blohmke, M. L. Mayer, A. C. Tang, A. F. Hirschfeld, C. D. Fjell, M. A. Sze, R. Falsafi, S. Wang, K. Hsu, M. A. Chilvers, J. C. Hogg, R. E. W. Hancock, S. E. Turvey. Atypical Activation of the Unfolded Protein Response in Cystic Fibrosis Airway Cells Contributes to p38 MAPK-Mediated Innate Immune Responses. The Journal of Immunology, 2012; DOI: 10.4049/jimmunol.1103661

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/BVOR-647sro/121107132920.htm

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Business Management (BSc) in the London area - The Student Room

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Sony Xperia TL for AT&T hands-on (video)

It's not unusual for a device to be sold under a couple of different names for the purposes of carrier branding, or to distinguish a global GSM model from its US bound LTE sibling. Sony seems to be trying for a record though, with the Xperia T adding a fourth rebranding. The company's latest flagship is landing on AT&T here in the US as the Xperia TL. At an event today in NYC the carrier broke out the curved 4.6-inch LTE Android device and we took the opportunity to give it yet another chance to impress us, after falling short of "wow" it's first few times around the block.

Back at IFA 2012, when we first got up close and personal with Sony's latest flagship, we were left feeling rather unimpressed and things haven't changed. The fit and finish of the TL just doesn't live up to the big boy breeches of its high-end ilk. Yes, it feels good in the hand, owed in part to that matte plastic back and subtle arc S-like curve, but the materials feel cheap. Thankfully, that sentiment doesn't spill over into its performance, as the 1.5GHz dual-core S4 powering the device does an admirable job keeping navigation brisk.

With a 720p HD Reality display powered by the outfit's Mobile BRAVIA Engine, you'd expect superb readability from the handset, especially in the dim light of this event. Though colors on the panel are bright and viewing angles seem to hold up fairly well, we did take issue with its overall brightness. Even pumped up to max, the screen just seemed a bit too dark for our tastes.

As with all things carrier-branded, this one lands with a host of AT&T apps onboard alongside three of Sony's own like Media, Album and Walkman. The build of Android on the device is still Ice Cream Sandwich with a light skin, but we were assured an upgrade to Jelly Bean is forthcoming and, given the company's track record, we're inclined to believe it. This official Bond Android phone's targeted for a holiday season release, so sit tight if you want to go all in on this Xperia. Check out the brief video tour after the break.

Gallery: Sony Xperia TL for AT&T

Joseph Volpe contributed to this report.

Continue reading Sony Xperia TL for AT&T hands-on (video)

Filed under: Cellphones, Mobile, Sony, AT&T

Sony Xperia TL for AT&T hands-on (video) originally appeared on Engadget on Thu, 04 Oct 2012 17:50:00 EDT. Please see our terms for use of feeds.

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inhabitat: Check out this gigantic LEGO church that popped up in the Netherlands! http://t.co/OGAErHGe

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Kelowna's sports community grateful to 'passionate' builder

A self-admitted football fanatic, Dr. Barry Urness is likely best known in Kelowna for founding the Okanagan Sun.

Still, as profound an effect as Urness had on the junior football club, his volunteer work in the community at large over three-plus decades reached well beyond the gridiron.

Former CHBC sportscaster Pat Kennedy first met Urness in 1981 and has marveled at his contributions to the City of Kelowna ever since.

"Barry was deeply involved in so many aspects of the community and he was so passionate about everything he did," said Kennedy. "His positive effects on the various committees, and groups and people were far-reaching. At the same time, he was humble and didn't want the accolades. Anyone who has lived here can be grateful for what Barry has done for Kelowna."

Urness passed away last Thursday after a battle with cancer. He was 69.

Lawrence Nagy first met Urness in the 1970s when Nagy was playing football at Immaculata.

The two would form a lifelong friendship, and in 1988 would be indelibly tied together in local sports history when the Sun won the Canadian junior football championship. Urness was the team president and Nagy, the head coach.

"Barry was passionate, he was a tireless worker and he didn't like the limelight," said Nagy, the head coach of the Sun when the club won national championships in 1988 and 2000.

"Barry's passion wasn't really about winning championships, it was more important to build things up from nothing, and to see other people benefit and have success from the work he did. If there was something you needed done, he was the guy to call. Barry was one of a kind."

Nagy credits Urness's guidance and hard work as the main catalyst behind the Sun's first Canadian junior football title.

Urness, who founded the club, then served as the team's first president in 1981 and 1982, returned to the post in 1988.

"When he came back on board he really made things possible for us," said Nagy. "I really believe he was the man behind that championship."

Urness also helped to resurrect high school football in the Central Okanagan, served as president of the Kelowna Amatuer Sports Society for 10 years, and served on the Kelowna Civic Awards Committee for 25 years.

In 2008, he founded the Central Okanagan Sports Hall of Fame Museum.

Earlier this month, Urness was inducted into the C.O. Hall of Fame in the special recognition category.

Pat Kennedy, the current managing director of the COSHF, said Urness was a true visionary.

"Through all the years what strikes me is that he had great vision," said Kennedy. "He would bring people on board, like Mayor Walter Gray, and they would immediately buy into what Barry was doing. Barry's biggest asset was gathering people and leading them, and that's why he got things done."

Urness was also a renowned and loyal Saskatchewan Roughrider football fan. His brother, Ted Urness, played for the Riders from 1961 to 1970.

In addition to his involvement with sports teams and organizations, Urness was involved in many other civic and community endeavors, including serving as provincial director of the Duke of Edinburgh Awards, and being the honourary chairman for the first two phases of the Mission Creek Greenway project.

Dr. Urness was also recognized by the Government of Canada with a Commemorative Medallion in honour of the 125th anniversary of Confederation.

Urness is survived by his wife Betty, sons David and Dean, and five?grandchildren.

A memorial service for Barry Urness will be held Wednesday, July 4 at 2 p.m. at Trinity Baptist Church.

?

?

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Bobcats select Michael Kidd-Gilchrist 2nd overall in NBA Draft

Posted by Inside Hoops

Jun 28

Michael Jordan?s Charlotte Bobcats have selected Kentucky small forward Michael Kidd-Gilchrist with the second overall pick in the NBA draft, marking the first time two players from the same school have gone first and second overall.

The Bobcats had been in trade talks with several teams regarding the No. 2 pick before making Kidd-Gilchrist their highest draft pick in franchise history since selecting Connecticut center Omeka Okafor second overall in 2004.

? Reported by Steve Reed of the Associated Press

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